Carbonic Anhydrase VI in Skin Wound Healing Study on Car6 Knockout Mice.

ABSTRACT: Carbonic anhydrases (CAs) contribute to tumor cell migration by generating an acidic environment through the conversion of carbon dioxide to bicarbonate and a proton. CA VI is secreted to milk and saliva, and it could contribute to wound closure, as a potential trophic factor, in animals that typically lick their wounds. Our aim was to investigate whether human CA VI improves skin-wound healing in full-thickness skin-wound models. The effect was studied in Car6-/- knockout mice and wild type littermates. Half of both mice strains were given topically administered, milk-derived CA VI after wounding and eight hours later. The amount of topically given CA VI exceeded the predicted amount of natural saliva-delivered CA VI. The healing was followed for seven days and studied from photographs an

SUBMITTER: Pemmari T 

PROVIDER: S-EPMC7404312 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature