SARS-CoV-2 S1 is superior to the RBD as a COVID-19 subunit vaccine antigen.

ABSTRACT: Since its emergence in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed into a global pandemic within a matter of months. While subunit vaccines are one of the prominent options for combating coronavirus disease 2019 (COVID-19), the immunogenicity of spike protein-based antigens remains unknown. When immunized in mice, the S1 domain induced much higher IgG and IgA antibody levels than the receptor-binding domain (RBD) and more efficiently neutralized SARS-CoV-2 when adjuvanted with alum. It is inferred that a large proportion of these neutralization epitopes are located in the S1 domain but outside the RBD and that some of these are spatial epitopes. This finding indicates that expression systems with posttranslational modification abilities are imp

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7404424 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature