ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain.

ABSTRACT: It has been suggested that some individuals may present genetic susceptibility to SARS-CoV-2 infection, with particular research interest in variants of the ACE2 and TMPRSS2 genes, involved in viral penetration into cells, in different populations and geographic regions, although insufficient information is currently available. This study addresses the apparently reasonable hypothesis that variants of these genes may modulate viral infectivity, making some individuals more vulnerable than others. Through whole-exome sequencing, the frequency of exonic variants of the ACE2, TMPRSS2, and Furin genes was analyzed in relation to presence or absence of SARS-CoV-2 infection in a familial multiple sclerosis cohort including 120 individuals from Madrid. The ACE2 gene showed a low level of polymorp

SUBMITTER: Torre-Fuentes L 

PROVIDER: S-EPMC7404937 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature