Presynaptic development is controlled by the core active zone proteins CAST/ELKS.

ABSTRACT:

Key points

CAST/ELKS are positive regulators of presynaptic growth and are suppressors of active zone expansion at the developing mouse calyx of Held. CAST/ELKS regulate all three Ca_V 2 subtype channel levels in the presynaptic terminal and not just Ca_V 2.1. The half-life of ELKS is on the timescale of days and not weeks. Synaptic transmission was not impacted by the loss of CAST/ELKS. CAST/ELKS are involved in pathways regulating morphological properties of presynaptic terminals during an early stage of circuit maturation.

Abstract

Many presynaptic active zone (AZ) proteins have multiple regulatory roles that vary during distinct stages of neuronal circuit development. The CAST/ELKS protein family are evolutionarily conserved presynaptic AZ molecules t

SUBMITTER: Radulovic T 

PROVIDER: S-EPMC7405068 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature