Association between prepregnancy body mass index and risk of congenital heart defects in offspring: an ambispective observational study in China.

ABSTRACT:

Background

Congenital heart defects (CHDs) are the most common birth defect around the world. Maternal prepregnancy obesity has been proposed as a risk factor of CHDs, but the relationship of CHD risk with over- and underweight is controversial, especially because body mass index (BMI) distribution differs between Asia and the West. The study aimed to examine the potential associations of maternal over- and underweight on risk of offspring CHDs.

Methods

An ambispective observational study involving 1206 fetuses with CHDs and 1112 fetuses without defects at seven hospitals in China was conducted. Standardized questionnaires were used to collect information on maternal prepregnancy weight and height, social demographic characteristics, living and occupational environments, and

SUBMITTER: Yuan X 

PROVIDER: S-EPMC7405421 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature