GSDB: a database of 3D chromosome and genome structures reconstructed from Hi-C data.

ABSTRACT: Advances in the study of chromosome conformation capture technologies, such as Hi-C technique - capable of capturing chromosomal interactions in a genome-wide scale - have led to the development of three-dimensional chromosome and genome structure reconstruction methods from Hi-C data. The three dimensional genome structure is important because it plays a role in a variety of important biological activities such as DNA replication, gene regulation, genome interaction, and gene expression. In recent years, numerous Hi-C datasets have been generated, and likewise, a number of genome structure construction algorithms have been developed.In this work, we outline the construction of a novel Genome Structure Database (GSDB) to create a comprehensive repository that contains 3D structures for Hi-

SUBMITTER: Oluwadare O 

PROVIDER: S-EPMC7405446 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature