Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples.

ABSTRACT:

Background

Studies suggest that alcohol consumption and alcohol use disorders have distinct genetic backgrounds.

Methods

We examined whether polygenic risk scores (PRS) for consumption and problem subscales of the Alcohol Use Disorders Identification Test (AUDIT-C, AUDIT-P) in the UK Biobank (UKB; N = 121 630) correlate with alcohol outcomes in four independent samples: an ascertained cohort, the Collaborative Study on the Genetics of Alcoholism (COGA; N = 6850), and population-based cohorts: Avon Longitudinal Study of Parents and Children (ALSPAC; N = 5911), Generation Scotland (GS; N = 17 461), and an independent subset of UKB (N = 245 947). Regression models and survival analyses tested whether the PRS were associated with the alcohol-related outcomes.

Results

In C

SUBMITTER: Johnson EC 

PROVIDER: S-EPMC7405725 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature