Voluntary Exercise Suppresses Choroidal Neovascularization in Mice.

ABSTRACT:

Purpose

To determine the effect of voluntary exercise on choroidal neovascularization (CNV) in mice.

Methods

Age-matched wild-type C57BL/6J mice were housed in cages equipped with or without running wheels. After four weeks of voluntary running or sedentariness, mice were subjected to laser injury to induce CNV. After surgical recovery, mice were placed back in cages with or without exercise wheels for seven days. CNV lesion volumes were measured by confocal microscopy. The effect of wheel running only in the seven days after injury was also evaluated. Macrophage abundance and cytokine expression were quantified.

Results

In the first study, exercise-trained mice exhibited a 45% reduction in CNV volume compared to sedentary mice. In the replication study, a 32% reducti

SUBMITTER: Makin RD 

PROVIDER: S-EPMC7405794 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature