Determinants of Quality of Life in Geographic Atrophy Secondary to Age-Related Macular Degeneration.

ABSTRACT: Purpose:To longitudinally evaluate vision-related quality of life (VRQoL) in geographic atrophy (GA) secondary to age-related macular degeneration (AMD) and define its relation to visual function and structural biomarkers. Methods:Patients with GA secondary to AMD were recruited in the context of the prospective, non-interventional, natural-history Directional Spread in Geographic-Atrophy study (NCT02051998). Fundus autofluorescence and infrared reflectance images were semi-automatically annotated for GA. Linear mixed-effects models were applied to investigate the association of putative determinants with the National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25) VRQoL. Results:A total of 87 patients with a mean age ± SD of 77.07 ± 7.49 years were included in the analysis. At

SUBMITTER: Kunzel SH 

PROVIDER: S-EPMC7405807 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature