Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19.

ABSTRACT: Severe disease of SARS-CoV-2 is characterized by vigorous inflammatory responses in the lung, often with a sudden onset after 5-7 days of stable disease. Efforts to modulate this hyperinflammation and the associated acute respiratory distress syndrome rely on the unraveling of the immune cell interactions and cytokines that drive such responses. Given that every patient is captured at different stages of infection, longitudinal monitoring of the immune response is critical and systems-level analyses are required to capture cellular interactions. Here, we report on a systems-level blood immunomonitoring study of 37 adult patients diagnosed with COVID-19 and followed with up to 14 blood samples from acute to recovery phases of the disease. We describe an IFNγ-eosinophil axis activated before

SUBMITTER: Rodriguez L 

PROVIDER: S-EPMC7405891 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature