Assessing Ganglion Cell Layer Topography in Human Albinism Using Optical Coherence Tomography.

ABSTRACT: Purpose:To test whether ganglion cell layer (GCL) and inner plexiform layer (IPL) topography is altered in albinism. Methods:Optical coherence tomography scans were analyzed in 30 participants with albinism and 25 control participants. Horizontal and vertical line scans were acquired at the fovea, then strip registered and averaged. The Duke Optical Coherence Tomography Retinal Analysis Program was used to automatically segment the combined GCL and IPL and total retinal thickness, followed by program-assisted manual segmentation of the boundary between the GCL and IPL. Layer thickness and area under the curve (AUC) were calculated within 2.5 mm of the fovea. Nasal-temporal and superior-inferior asymmetry were calculated as an AUC ratio in each quadrant. Results:GCL and IPL topography varie

SUBMITTER: Woertz EN 

PROVIDER: S-EPMC7405956 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature