Extracellular Vesicle cystatin c is associated with unstable angina in troponin negative patients with acute chest pain.

ABSTRACT:

Background

Despite the use of high-sensitive cardiac troponin there remains a group of high-sensitive cardiac troponin negative patients with unstable angina with a non-neglectable risk for future adverse cardiovascular events, emphasising the need for additional risk stratification. Plasma extracellular vesicles are small bilayer membrane vesicles known for their potential role as biomarker source. Their role in unstable angina remains unexplored. We investigate if extracellular vesicle proteins are associated with unstable angina in patients with chest pain and low high-sensitive cardiac troponin.

Methods

The MINERVA study included patients presenting with acute chest pain but no acute coronary syndrome. We performed an exploratory retrospective case-control analysis among

SUBMITTER: Dekker M 

PROVIDER: S-EPMC7406038 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature