The effect of hydration status on plasma FGF21 concentrations in humans: A subanalysis of a randomised crossover trial.

ABSTRACT:

Aim

Fibroblast growth factor 21 (FGF21) has recently been implicated in thirst in rodent models. The mechanisms for this are currently uncertain, and it is unclear whether hydration status can alter FGF21 concentrations, potentially providing an additional mechanism by which hypohydration induces thirst. The aim of this study is therefore to understand whether hydration status can alter circulating FGF21 in humans.

Methods

Using a heat tent and fluid restriction, we induced hypohydration (1.9% body mass loss) in 16 healthy participants (n = 8 men), and compared their glycaemic regulation to a rehydration protocol (heat tent and fluid replacement) in a randomised crossover design.

Results

After the hypohydration procedure, urine specific gravity, urine and serum osmola

SUBMITTER: Carroll HA 

PROVIDER: S-EPMC7406048 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature