A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility.

ABSTRACT: Aromatase activity has commonly been associated with male infertility characterized by testicular dysfunction with low serum testosterone and/or testosterone to estradiol ratio. In this subset of patients, and particularly in those with hypogonadism, elevated levels of circulating estradiol may establish a negative feedback on the hypothalamic-pituitary-testicular axis by suppressing follicle-stimulating hormone (FSH) and luteinizing hormone (LH) production and impaired spermatogenesis. Hormonal manipulation via different agents such as selective estrogen modulators or aromatase inhibitors to increase endogenous testosterone production and improve spermatogenesis in the setting of infertility is an off-label option for treatment. We carried out a systematic review and meta-analysis of the

SUBMITTER: Del Giudice F 

PROVIDER: S-EPMC7406101 | biostudies-literature | 2020 Jul-Aug

REPOSITORIES: biostudies-literature