Ontology highlight
ABSTRACT:
SUBMITTER: Xu H
PROVIDER: S-EPMC7406248 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Xu Hu H Fang Bingying B Du Shengnan S Wang Sailun S Li Qingwei Q Jia Xiao X Bao Chengzhen C Ye Lan L Sui Xue X Qian Lei L Luan Zhilin Z Yang Guangrui G Zheng Feng F Wang Nanping N Chen Lihong L Zhang Xiaoyan X Guan Youfei Y
JCI insight 20200709 13
Prostaglandin E2 and its cognate EP1-4 receptors play important roles in blood pressure (BP) regulation. Herein, we show that endothelial cell-specific (EC-specific) EP4 gene-knockout mice (EC-EP4-/-) exhibited elevated, while EC-specific EP4-overexpression mice (EC-hEP4OE) displayed reduced, BP levels compared with the control mice under both basal and high-salt diet-fed conditions. The altered BP was completely abolished by treatment with l-NG-nitro-l-arginine methyl ester (l-NAME), a competit ...[more]