Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC7406266 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Liu Jie J Xavy Seethu S Mihardja Shirley S Chen Sharline S Sompalli Kavitha K Feng Dongdong D Choi Timothy T Agoram Balaji B Majeti Ravindra R Weissman Irving L IL Volkmer Jens-Peter JP
JCI insight 20200618 12
The CD47/signal regulatory protein α (Cd47/SIRPα)interaction provides a macrophage immune checkpoint pathway that plays a critical role in cancer immune evasion across multiple cancers. Here, we report the engineering of a humanized anti-SIRPα monoclonal antibody (1H9) for antibody target cancer therapy. 1H9 has broad activity across a wide range of SIRPα variants. Binding of 1H9 to SIRPα blocks its interaction with CD47, thereby promoting macrophage-mediated phagocytosis of cancer cells. Precli ...[more]