Integrated urine proteomics and renal single-cell genomics identify an IFN-γ response gradient in lupus nephritis.

ABSTRACT: Lupus nephritis, one of the most serious manifestations of systemic lupus erythematosus (SLE), has a heterogeneous clinical and pathological presentation. For example, proliferative nephritis identifies a more aggressive disease class that requires immunosuppression. However, the current classification system relies on the static appearance of histopathological morphology, which does not capture differences in the inflammatory response. Therefore, a biomarker grounded in the disease biology is needed in order to understand the molecular heterogeneity of lupus nephritis and identify immunologic mechanism and pathways. Here, we analyzed the patterns of 1000 urine protein biomarkers in 30 patients with active lupus nephritis. We found that patients stratify over a chemokine gradient inducible

SUBMITTER: Fava A 

PROVIDER: S-EPMC7406291 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature