Maternal hypothyroidism in mice influences glucose metabolism in adult offspring.

ABSTRACT:

Aims/hypothesis

During pregnancy, maternal metabolic disease and hormonal imbalance may alter fetal beta cell development and/or proliferation, thus leading to an increased risk for developing type 2 diabetes in adulthood. Although thyroid hormones play an important role in fetal endocrine pancreas development, the impact of maternal hypothyroidism on glucose homeostasis in adult offspring remains poorly understood.

Methods

We investigated this using a mouse model of hypothyroidism, induced by administration of an iodine-deficient diet supplemented with propylthiouracil during gestation.

Results

Here, we show that, when fed normal chow, adult mice born to hypothyroid mothers were more glucose-tolerant due to beta cell hyperproliferation (two- to threefold increase in

SUBMITTER: Kemkem Y 

PROVIDER: S-EPMC7406527 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature