Heterotypic immunity against vaccinia virus in an HLA-B*07:02 transgenic mousepox infection model.

ABSTRACT: Vaccination with vaccinia virus (VACV) elicits heterotypic immunity to smallpox, monkeypox, and mousepox, the mechanistic basis for which is poorly understood. It is generally assumed that heterotypic immunity arises from the presentation of a wide array of VACV-derived, CD8⁺ T cell epitopes that share homology with other poxviruses. Herein this assumption was tested using a large panel of VACV-derived peptides presented by HLA-B*07:02 (B7.2) molecules in a mousepox/ectromelia virus (ECTV)-infection, B7.2 transgenic mouse model. Most dominant epitopes recognized by ECTV- and VACV-reactive CD8⁺ T cells overlapped significantly without altering immunodominance hierarchy. Further, several epitopes recognized by ECTV-reactive CD8⁺ T cells were not recognized by

SUBMITTER: Kumar A 

PROVIDER: S-EPMC7406653 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature