Estimated GFR Trajectories in Pediatric and Adult Nephrotic Syndrome: Results From the Nephrotic Syndrome Study Network (NEPTUNE).

ABSTRACT:

Rationale & objective

Surrogate outcomes for end-stage kidney disease often assume linear changes, which may not reflect true estimated glomerular filtration rate (eGFR) trajectories. This study's objective was to characterize nonlinear eGFR trajectories in nephrotic syndrome.

Study design

Observational cohort study.

Setting & participants

Nephrotic Syndrome Study Network (NEPTUNE) is a multicenter study of adult and pediatric patients with proteinuria enrolled at clinically indicated kidney biopsy or initial presentation of disease (pediatric only).

Predictors

Patient demographic, clinical, and pathology variables at study enrollment and follow-up time.

Outcome

eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (patients ≥ 1

SUBMITTER: Smith AR 

PROVIDER: S-EPMC7406843 | biostudies-literature | 2020 Jul-Aug

REPOSITORIES: biostudies-literature