Association Between Chronic Kidney Disease-Mineral Bone Disease (CKD-MBD) and Cognition in Children: Chronic Kidney Disease in Children (CKiD) Study.

ABSTRACT:

Rationale & objective

Chronic kidney disease (CKD) in children is associated with cognitive dysfunction that affects school performance and quality of life. The relationship between CKD-mineral and bone disorder and cognitive function in children is unknown.

Study design

Observational study.

Participants

702 children enrolled in the Chronic Kidney Disease in Children (CKiD) Study.

Predictors

Plasma fibroblast growth factor 23 (FGF-23), parathyroid hormone (PTH), calcium, phosphorus, 25 hydroxyvitamin D (25[OH]D), and 1,25 dihydroxyvitamin D (1,25[OH]₂D).

Outcomes

Neurocognitive tests of intelligence, academic achievement, and executive functions.

Analytical approach

Linear regression models to analyze the cross-sectional associations be

SUBMITTER: Yokoyama JS 

PROVIDER: S-EPMC7406846 | biostudies-literature | 2020 Jul-Aug

REPOSITORIES: biostudies-literature