COVID-19-Associated Collapsing Focal Segmental Glomerulosclerosis: A Report of 2 Cases.

ABSTRACT: Collapsing glomerulopathy is an aggressive form of focal segmental glomerulosclerosis with diverse causes. The presence of the apolipoprotein L1 (APOL1) high-risk genotype is a major risk factor for collapsing glomerulopathy in African Americans. Coronavirus disease 2019 (COVID-19) is an emerging pandemic with predominant respiratory manifestations. However, kidney involvement is being frequently noted and is associated with higher mortality. Currently, kidney pathology data for COVID-19 are scant and mostly come from postmortem findings. We report 2 African American patients who developed acute kidney injury and proteinuria in temporal association with COVID-19 infection. Kidney biopsy specimens showed collapsing glomerulopathy, endothelial tubuloreticular inclusions, and acute tub

SUBMITTER: Sharma Y 

PROVIDER: S-EPMC7406850 | biostudies-literature | 2020 Jul-Aug

REPOSITORIES: biostudies-literature