Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic Intervention.

ABSTRACT: With the objective of linking early findings relating to the novel SARS-CoV-2 coronavirus with potentially informative findings from prior research literature and to promote investigation toward therapeutic response, a coherent cellular and molecular pathway is proposed for COVID-19. The pathway is consistent with a broad range of observed clinical features and biological markers and captures key mediators of pathophysiology. In this proposed pathway, membrane fusion and cytoplasmic entry of SARS-CoV-2 virus via ACE2 and TMPRSS2-expressing respiratory epithelial cells, including pulmonary type-II pneumocytes, provoke an initial immune response featuring inflammatory cytokine production coupled with a weak interferon response, particularly in IFN-λ-dependent epithelial defense. Diffe

SUBMITTER: Hussman JP 

PROVIDER: S-EPMC7406916 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature