Novel Antimicrobials from Uncultured Bacteria Acting against Mycobacterium tuberculosis.

ABSTRACT: Mycobacterium tuberculosis, which causes tuberculosis (TB), is estimated to infect one-third of the world's population. The overall burden and the emergence of drug-resistant strains of Mycobacterium tuberculosis underscore the need for new therapeutic options against this important human pathogen. Our recent work demonstrated the success of natural product discovery in identifying novel compounds with efficacy against Mycobacterium tuberculosis Here, we improve on these methods by combining improved isolation and Mycobacterium tuberculosis selective screening to identify three new anti-TB compounds: streptomycobactin, kitamycobactin, and amycobactin. We were unable to obtain mutants resistant to streptomycobactin, and its target remains to be elucidated. We ide

SUBMITTER: Quigley J 

PROVIDER: S-EPMC7407088 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature