Deamidated Human Triosephosphate Isomerase is a Promising Druggable Target.

ABSTRACT: Therapeutic strategies for the treatment of any severe disease are based on the discovery and validation of druggable targets. The human genome encodes only 600-1500 targets for small-molecule drugs, but posttranslational modifications lead to a considerably larger druggable proteome. The spontaneous conversion of asparagine (Asn) residues to aspartic acid or isoaspartic acid is a frequent modification in proteins as part of the process called deamidation. Triosephosphate isomerase (TIM) is a glycolytic enzyme whose deamidation has been thoroughly studied, but the prospects of exploiting this phenomenon for drug design remain poorly understood. The purpose of this study is to demonstrate the properties of deamidated human TIM (HsTIM) as a selective molecular target. Using in silico predict

SUBMITTER: Enriquez-Flores S 

PROVIDER: S-EPMC7407242 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature