Expression of Annexin A2 Promotes Cancer Progression in Estrogen Receptor Negative Breast Cancers.

ABSTRACT: When breast cancer progresses to a metastatic stage, survival rates decline rapidly and it is considered incurable. Thus, deciphering the critical mechanisms of metastasis is of vital importance to develop new treatment options. We hypothesize that studying the proteins that are newly synthesized during the metastatic processes of migration and invasion will greatly enhance our understanding of breast cancer progression. We conducted a mass spectrometry screen following bioorthogonal noncanonical amino acid tagging to elucidate changes in the nascent proteome that occur during epidermal growth factor stimulation in migrating and invading cells. Annexin A2 was identified in this screen and subsequent examination of breast cancer cell lines revealed that Annexin A2 is specifically upregulate

SUBMITTER: Mahdi AF 

PROVIDER: S-EPMC7407301 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature