The Disordered Cellular Multi-Tasker WIP and Its Protein-Protein Interactions: A Structural View.

ABSTRACT: WASp-interacting protein (WIP), a regulator of actin cytoskeleton assembly and remodeling, is a cellular multi-tasker and a key member of a network of protein-protein interactions, with significant impact on health and disease. Here, we attempt to complement the well-established understanding of WIP function from cell biology studies, summarized in several reviews, with a structural description of WIP interactions, highlighting works that present a molecular view of WIP's protein-protein interactions. This provides a deeper understanding of the mechanisms by which WIP mediates its biological functions. The fully disordered WIP also serves as an intriguing example of how intrinsically disordered proteins (IDPs) exert their function. WIP consists of consecutive small functional domains and m

SUBMITTER: Sokolik CG 

PROVIDER: S-EPMC7407642 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature