Changes and roles of intestinal fungal microbiota in coronary heart disease complicated with nonalcoholic fatty liver disease.

ABSTRACT:

Background

Patients who suffered coronary heart disease (CHD) complicated with non-alcoholic fatty liver disease (NAFLD) were reported to have worse cardiac function and clinical outcomes than patients with CHD only. The mechanism was unclear. Previous study focused on the metabolism and showed it could be regulated by the microbiota. Few studies related to fungi. We aimed to investigate the characteristics of intestinal fungal microbiota in CHD patients complicated with NAFLD (CHD-NAFLD).

Methods

72 People were recruited and equally divided into three groups, including CHD patients (without NAFLD), CHD-NAFLD patients, and healthy controls (HCs). Fecal samples were collected. The Illumina sequencing of the internal transcribed spacer 3-4 rRNA was applied.

Results

The

SUBMITTER: Xu J 

PROVIDER: S-EPMC7407707 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature