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The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier.

ABSTRACT: Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation. Its sole entry point into mitochondria is through the recently identified mitochondrial pyruvate carrier (MPC). In this review, we report the latest findings on the physiology of the MPC and we discuss how a dysfunctional MPC can lead to diverse pathologies, including neurodegenerative diseases, metabolic disorders, and cancer.

SUBMITTER: Zangari J 

PROVIDER: S-EPMC7407832 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier.

Zangari Joséphine J   Petrelli Francesco F   Maillot Benoît B   Martinou Jean-Claude JC  

Biomolecules 20200717 7

Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation. Its sole entry point into mitochondria is through the recently identified mitochondrial pyruvate carrier (MPC). In this review, we report the latest findings on the physiology of the MPC and we discuss how a dysfunctional MPC can lead to diverse pathologies, including neurodegenerativ  ...[more]

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