Inter-Tumor Heterogeneity-Melanomas Respond Differently to GM-CSF-Mediated Activation.

ABSTRACT: Granulocyte-monocyte colony stimulating factor (GM-CSF) is used as an adjuvant in various clinical and preclinical studies with contradictory results. These were attributed to opposing effects of GM-CSF on the immune or myeloid systems of the treated patients or to lack of optimal dosing regimens. The results of the present study point to inter-tumor heterogeneity as a possible mechanism accounting for the contrasting responses to GM-CSF incorporating therapies. Employing xenograft models of human melanomas in nude mice developed in our lab, we detected differential functional responses of melanomas from different patients to GM-CSF both in vitro as well as in vivo. Whereas cells of one melanoma acquired pro metastatic features following exposure to GM-CSF, cells from another melanoma eith

SUBMITTER: Moshe A 

PROVIDER: S-EPMC7407964 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature