Development of Artificial Plasma Membranes Derived Nanovesicles Suitable for Drugs Encapsulation.

ABSTRACT: Extracellular vesicles (EVs) are considered as promising nanoparticle theranostic tools in many pathological contexts. The increasing clinical employment of therapeutic nanoparticles is contributing to the development of a new research area related to the design of artificial EVs. To this aim, different approaches have been described to develop mimetic biologically functional nanovescicles. In this paper, we suggest a simplified procedure to generate plasma membrane-derived nanovesicles with the possibility to efficiently encapsulate different drugs during their spontaneously assembly. After physical and molecular characterization by Tunable Resistive Pulse Sensing (TRPS) technology, transmission electron microscopy, and flow cytometry, as a proof of principle, we have loaded into mimetic

SUBMITTER: Martinelli C 

PROVIDER: S-EPMC7408059 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature