Bifunctional Peptide-Polymer Conjugate-Based Fibers via a One-Pot Tandem Disulfide Reduction Coupled to a Thio-Bromo "Click" Reaction.

ABSTRACT: In view of the potential applications of fibers in material sciences and biomedicine, an effective synthetic strategy is described to construct peptide-based bifunctional polymeric conjugates for supramolecular self-association in solution. A direct coupling method of an α-acyl-brominated peptide Phe-Phe-Phe-Phe (FFFF) with a disulfide-bridged polymeric scaffold of poly(ethylene glycol) (PEG) (M _n,GPC = 8700 g mol^-1, Đ = 2.02) is reported to readily prepare the bi-headed conjugate FFFF-PEG-FFFF (M _n,GPC = 3800 g mol^-1, Đ = 1.10) via a one-pot, tandem disulfide reduction (based on tris(2-carboxyethyl)phosphine hydrochloride (TCEP)) coupled to a thio-bromo "click" reaction. The conjugate was investigated via transmission

SUBMITTER: Kumar S 

PROVIDER: S-EPMC7408259 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature