Mycobacteria-Based Vaccines as Immunotherapy for Non-urological Cancers.

ABSTRACT: The arsenal against different types of cancers has increased impressively in the last decade. The detailed knowledge of the tumor microenvironment enables it to be manipulated in order to help the immune system fight against tumor cells by using specific checkpoint inhibitors, cell-based treatments, targeted antibodies, and immune stimulants. In fact, it is widely known that the first immunotherapeutic tools as immune stimulants for cancer treatment were bacteria and still are; specifically, the use of Mycobacterium bovis bacillus Calmette-Guérin (BCG) continues to be the treatment of choice for preventing cancer recurrence and progression in non-invasive bladder cancer. BCG and also other mycobacteria or their components are currently under study for the immunotherapeutic treatment of dif

SUBMITTER: Noguera-Ortega E 

PROVIDER: S-EPMC7408281 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature