Parental asthma occurrence, exacerbations and risk of attention-deficit/hyperactivity disorder.

ABSTRACT:

Objective

To investigate whether intrauterine exposure to maternal asthma or asthma exacerbations increases the risk of attention-deficit/hyperactivity disorder (ADHD).

Methods

Using Danish register data, this cohort study comprised of 961,202 live singletons born in Denmark during 1997-2012. Children were followed to a maximum of 20.0 years from birth until the first of ADHD-diagnosis/prescription, emigration, death, or 31 December 2016. Cox regression models were used to evaluate the association between maternal or paternal asthma, asthma exacerbations and offspring ADHD.

Results

During 11.4 million person-years of follow-up, 27,780 (2.9%) children were identified as having ADHD. ADHD risk was increased among offspring born to asthmatic mothers (hazard ratio (HR) 1.

SUBMITTER: Liu X 

PROVIDER: S-EPMC7408292 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature