[^nat/44Sc(pypa)]^-: Thermodynamic Stability, Radiolabeling, and Biodistribution of a Prostate-Specific-Membrane-Antigen-Targeting Conjugate.

ABSTRACT: ⁴⁴Sc is an attractive positron-emitting radionuclide for PET imaging; herein, a new complex of the Sc³⁺ ion with nonmacrocyclic chelator H₄pypa was synthesized and characterized with high-resolution electrospray-ionization mass spectrometry (HR-ESI-MS), as well as different nuclear magnetic resonance (NMR) spectroscopic techniques (¹H, ¹³C, ¹H-¹³C HSQC, ¹H-¹³C HMBC, COSY, and NOESY). In aqueous solution (pH = 7), [Sc(pypa)]^- presented two isomeric forms, the structures of which were predicted using density functional theory (DFT) calculation with a small energy difference of 22.4 kJ/mol, explaining their coexistence. [Sc(pypa)]^- was found to have superior thermodynamic s

SUBMITTER: Li L 

PROVIDER: S-EPMC7408314 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature