Synthesis and Anticancer Activity of Dimeric Polyether Ionophores.

ABSTRACT: Polyether ionophores represent a group of natural lipid-soluble biomolecules with a broad spectrum of bioactivity, ranging from antibacterial to anticancer activity. Three seem to be particularly interesting in this context, namely lasalocid acid, monensin, and salinomycin, as they are able to selectively target cancer cells of various origin including cancer stem cells. Due to their potent biological activity and abundant availability, some research groups around the world have successfully followed semi-synthetic approaches to generate original derivatives of ionophores. However, a definitely less explored avenue is the synthesis and functional evaluation of their multivalent structures. Thus, in this paper, we describe the synthetic access to a series of original homo- and heterodimers

SUBMITTER: Sulik M 

PROVIDER: S-EPMC7408349 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature