A Microfluidic Probe Integrated Device for Spatiotemporal 3D Chemical Stimulation in Cells.

ABSTRACT: Numerous in vitro studies have been conducted in conventional static cell culture systems. However, most of the results represent an average response from a population of cells regardless of their local microenvironment. A microfluidic probe is a non-contact technology that has been widely used to perform local chemical stimulation within a restricted space, providing elaborated modulation and analysis of cellular responses within the microenvironment. Although microfluidic probes developed earlier have various potential applications, the two-dimensional structure can compromise their functionality and flexibility for practical use. In this study, we developed a three-dimensional microfluidic probe integrated device equipped with vertically oriented microchannels to overcome crucial challe

SUBMITTER: Shinha K 

PROVIDER: S-EPMC7408473 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature