Effect of Geometric Curvature on Collective Cell Migration in Tortuous Microchannel Devices.

ABSTRACT: Collective cell migration is an essential phenomenon in many naturally occurring pathophysiological processes, as well as in tissue engineering applications. Cells in tissues and organs are known to sense chemical and mechanical signals from the microenvironment and collectively respond to these signals. For the last few decades, the effects of chemical signals such as growth factors and therapeutic agents on collective cell behaviors in the context of tissue engineering have been extensively studied, whereas those of the mechanical cues have only recently been investigated. The mechanical signals can be presented to the constituent cells in different forms, including topography, substrate stiffness, and geometrical constraint. With the recent advancement in microfabrication technology, re

SUBMITTER: Mazalan MB 

PROVIDER: S-EPMC7408538 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature