The Role of Dysfunctional Adipose Tissue in Pancreatic Cancer: A Molecular Perspective.

ABSTRACT: Pancreatic cancer (PC) is a lethal malignancy with rising incidence and limited therapeutic options. Obesity is a well-established risk factor for PC development. Moreover, it negatively affects outcome in PC patients. Excessive fat accumulation in obese, over- and normal-weight individuals induces metabolic and inflammatory changes of adipose tissue microenvironment leading to a dysfunctional adipose "organ". This may drive the association between abnormal fat accumulation and pancreatic cancer. In this review, we describe several molecular mechanisms that underpin this association at both local and systemic levels. We focus on the role of adipose tissue-derived circulating factors including adipokines, hormones and pro-inflammatory cytokines, as well as on the impact of the local adipose

SUBMITTER: Brocco D 

PROVIDER: S-EPMC7408631 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature