Evolution of Gut Microbiome and Metabolome in Suspected Necrotizing Enterocolitis: A Case-Control Study.

ABSTRACT:

Background

Necrotizing enterocolitis (NEC) is a devastating condition in preterm infants due to multiple factors, including gut microbiota dysbiosis. NEC development is poorly understood, due to the focus on severe NEC (NEC-2/3).

Methods

We studied the gut microbiota, microbiome and metabolome of children with suspected NEC (NEC-1).

Results

NEC-1 gut microbiota had a higher abundance of the Streptococcus (second 10-days of life) and Staphylococcus (third 10-days of life) species. NEC-1 children showed a microbiome evolution in the third 10-days of life being the most divergent, and were associated with a different metabolomic signature than in healthy children. The NEC-1 microbiome had increased glycosaminoglycan degradation and lysosome activity by the first 10-days

SUBMITTER: Brehin C 

PROVIDER: S-EPMC7408695 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature