HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration.

ABSTRACT: Immune attacks are key issues for cell transplantation. To assess the safety and the immune reactions after iPS cells-derived retinal pigment epithelium (iPS-RPE) transplantation, we transplanted HLA homozygote iPS-RPE cells established at an iPS bank in HLA-matched patients with exudative age-related macular degeneration. In addition, local steroids without immunosuppressive medications were administered. We monitored immune rejections by routine ocular examinations as well as by lymphocytes-graft cells immune reaction (LGIR) tests using graft RPE and the patient's blood cells. In all five of the cases that underwent iPS-RPE transplantation, the presence of graft cells was indicated by clumps or an area of increased pigmentation at 6 months, which became stable with no further abnormal gr

SUBMITTER: Sugita S 

PROVIDER: S-EPMC7408794 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature