Dataset Information

Strong Correlation of Renal Function with Choroidal Thickness in Patients with Type 2 Diabetes: Retrospective Cross-Sectional Study.

ABSTRACT: The purpose of this study was to analyze the correlation between renal function and subfoveal choroidal thickness (SFChT) in treatment-naïve proliferative diabetic retinopathy (PDR) patients. This study included 85 eyes of 52 treatment-naïve PDR patients who underwent kidney function testing and urinalysis and 42 eyes of 33 age-matched controls. Treatment-naïve eyes with PDR were categorized into pachychoroid and leptochoroid groups based on the SFChT of the control group. Kidney function profiles were compared between pachychoroid and leptochoroid groups; the relationship between kidney function profile and SFChT was evaluated using regression analysis. Compared with the pachychoroid group, the leptochoroid group had significantly higher serum creatinine (p = 0.026), cystatin C (p = 0.004), and phosphorus (p < 0.001) levels and a lower estimated glomerular filtration rate (eGFR) (p < 0.001). Multivariate linear regression analyses showed that SFChT was positively correlated with eGFR (Cystatin C) (p = 0.007) and negatively correlated with serum phosphorus (p = 0.001). SFChT of patients with eGFR < 30 mL/min/1.73 m2 and serum phosphorus level ≥4.0 mg/dL was less than that of patients with higher eGFR and lower serum phosphorus level. The choroidal thickness of treatment-naïve PDR patients is closely affected by renal function. Kidney function test should be considered if SFChT of patients with treatment-naïve PDR is reduced.

SUBMITTER: Choi MG

PROVIDER: S-EPMC7408798 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Strong Correlation of Renal Function with Choroidal Thickness in Patients with Type 2 Diabetes: Retrospective Cross-Sectional Study.

Choi Min Gyu MG Kim Jee Taek JT

Journal of clinical medicine 20200709 7

The purpose of this study was to analyze the correlation between renal function and subfoveal choroidal thickness (SFChT) in treatment-naïve proliferative diabetic retinopathy (PDR) patients. This study included 85 eyes of 52 treatment-naïve PDR patients who underwent kidney function testing and urinalysis and 42 eyes of 33 age-matched controls. Treatment-naïve eyes with PDR were categorized into pachychoroid and leptochoroid groups based on the SFChT of the control group. Kidney function profil ...[more]

PMID: 32659991

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Project description:BackgroundAutism spectrum disorder (ASD) often presents with atypical visual processing, prompting investigation into its connection with retinal features. This study aimed to (I) compare intraretinal layer thickness in the peripapillary region between ASD and neurotypical (NT) groups, (II) assess associations between intraretinal layer thickness and clinical parameters (social functioning and cognitive levels) in ASD subjects, and (III) evaluate the potential of intraretinal layer thickness as a biomarker for ASD.MethodsParticipants were recruited through convenience sampling from the Children's Mental Health Research Center at The Affiliated Brain Hospital of Nanjing Medical University and the Department of Ophthalmology at The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, between December 2019 and August 2023. Intraretinal layer thickness in peripapillary region was quantified using optic coherence tomography images with automated layer segmentation performed by OCTExplorer software on 47 individuals with ASD (aged 7-13 years) and age- and sex-matched NT controls. Inter-group comparisons were conducted using unpaired t-tests, Welch's t-tests, or Mann-Whitney U tests as appropriate. Correlations with social functioning (measured by Social Responsiveness Scale scores) and cognitive levels [measured by total intelligence quotient (IQ) scores] were examined using the Spearman correlation coefficient. Stepwise regression analysis was conducted to assess predictive power.ResultsSignificant inter-group differences (P<0.05) were observed in ganglion cell layer and inner nuclear layer (INL) thickness across global and specific quadrant regions. Participants had a mean age of 9.57±1.83 years in the ASD group and 9.89±1.70 years in the age-matched NT group. While no correlation was found between retinal sublayer thickness and social functioning on ASD subjects (all P>0.05), there was a notable correlation between INL thickness in the infero-nasal quadrant and cognitive level (r=0.381, P=0.014). Stepwise regression analysis identified global INL thickness as a significant predictor of total IQ scores (β=3.986, P=0.034), with an R2 of 0.110 and a root mean square error of 21.900.ConclusionsThis study highlights significant differences in retinal features between ASD and NT groups, with implications for understanding ASD pathogenesis and complexity. The findings suggest that easily observable retinal features hold promise as biomarkers for ASD, warranting further investigation.

Dataset Information

Strong Correlation of Renal Function with Choroidal Thickness in Patients with Type 2 Diabetes: Retrospective Cross-Sectional Study.

Publications

Strong Correlation of Renal Function with Choroidal Thickness in Patients with Type 2 Diabetes: Retrospective Cross-Sectional Study.

Similar Datasets

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