Chemokine Receptors CCR1 and CCR2 on Peripheral Blood Mononuclear Cells of Newly Diagnosed Patients with the CD38-Positive Chronic Lymphocytic Leukemia.

ABSTRACT: Chemokines and their receptors direct migration and infiltration of immune cells. CCR1 and CCR2 maintain sequence similarity and respond to a number of the same chemokines secreted in lymphoid organs. Expression of CD38 on leukemic cells has been associated with poor clinical outcomes in patients with chronic lymphocytic leukemia (CLL) and is considered as the negative predictor of progression. In our study of newly diagnosed CLL patients, which included 39 CD38-positive and 22 CD38-negative patients, CCR1 and/or CCR2 were always detected, using flow cytometry, on the peripheral blood (PB) CD19⁺CD5⁺ lymphocytes in patients with >30% of the CD38⁺ CD19⁺CD5⁺ lymphocytes (n = 16). Spearman's rank correlation analysis determined corr

SUBMITTER: Kholodnyuk I 

PROVIDER: S-EPMC7408836 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature