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Sjogren's Syndrome Minor Salivary Gland CD4⁺ Memory T Cells Associate with Glandular Disease Features and have a Germinal Center T Follicular Helper Transcriptional Profile.

ABSTRACT: To assess the types of salivary gland (SG) T cells contributing to Sjögren's syndrome (SS), we evaluated SG T cell subtypes for association with disease features and compared the SG CD4⁺ memory T cell transcriptomes of subjects with either primary SS (pSS) or non-SS sicca (nSS). SG biopsies were evaluated for proportions and absolute numbers of CD4⁺ and CD8⁺ T cells. SG memory CD4⁺ T cells were evaluated for gene expression by microarray. Differentially-expressed genes were identified, and gene set enrichment and pathways analyses were performed. CD4⁺CD45RA^- T cells were increased in pSS compared to nSS subjects (33.2% vs. 22.2%, p < 0.0001), while CD8⁺CD45RA^- T cells were decreased (38.5% vs. 46

SUBMITTER: Joachims ML

PROVIDER: S-EPMC7408878 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Dataset Information

Sjogren's Syndrome Minor Salivary Gland CD4⁺ Memory T Cells Associate with Glandular Disease Features and have a Germinal Center T Follicular Helper Transcriptional Profile.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Sjogren's Syndrome Minor Salivary Gland CD4+ Memory T Cells Associate with Glandular Disease Features and have a Germinal Center T Follicular Helper Transcriptional Profile.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Sjogren's Syndrome Minor Salivary Gland CD4⁺ Memory T Cells Associate with Glandular Disease Features and have a Germinal Center T Follicular Helper Transcriptional Profile.