Atherosclerosis as Pathogenetic Substrate for Sars-Cov2 Cytokine Storm.

ABSTRACT: The severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) outbreak is a public health emergency affecting different regions around the world. The lungs are often damaged due to the presence of Sars-CoV-2 binding receptor ACE2 on epithelial alveolar cells. Severity of infection varies from complete absence of symptomatology to more aggressive symptoms, characterized by sudden acute respiratory distress syndrome (ARDS), multiorgan failure, and sepsis, requiring treatment in intensive care unit (ICU). It is not still clear why the immune system is not able to efficiently suppress viral replication in a small percentage of patients. It has been documented as pathological conditions affecting the cardiovascular system, strongly associated to atherosclerotic progression, such as heart fai

SUBMITTER: Vinciguerra M 

PROVIDER: S-EPMC7408959 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature