Ontology highlight
ABSTRACT:
SUBMITTER: Khou S
PROVIDER: S-EPMC7408986 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Cancers 20200710 7
Cutaneous squamous cell carcinoma (cSCC) development has been linked to immune dysfunctions but the mechanisms are still unclear. Here, we report a progressive infiltration of tumor-associated neutrophils (TANs) in precancerous and established cSCC lesions from chemically induced skin carcinogenesis. Comparative in-depth gene expression analyses identified a predominant protumor gene expression signature of TANs in lesions compared to their respective surrounding skin. In addition, in vivo deple ...[more]