Altered Metabolome of Lipids and Amino Acids Species: A Source of Early Signature Biomarkers of T2DM.

ABSTRACT: Diabetes mellitus, a disease of modern civilization, is considered the major mainstay of mortalities around the globe. A great number of biochemical changes have been proposed to occur at metabolic levels between perturbed glucose, amino acid, and lipid metabolism to finally diagnoe diabetes mellitus. This window period, which varies from person to person, provides us with a unique opportunity for early detection, delaying, deferral and even prevention of diabetes. The early detection of hyperglycemia and dyslipidemia is based upon the detection and identification of biomarkers originating from perturbed glucose, amino acid, and lipid metabolism. The emerging "OMICS" technologies, such as metabolomics coupled with statistical and bioinformatics tools, proved to be quite useful to study cha

SUBMITTER: Hameed A 

PROVIDER: S-EPMC7409008 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature