Ribosomal Protein uL11 as a Regulator of Metabolic Circuits Related to Aging and Cell Cycle.

ABSTRACT: Aging is a biological phenomenon common to all living organisms. It is thought that the rate of aging is influenced by diverse factors, in many cases related to the control of energy metabolism, i.e., the so-called pro-longevity effects of starvation. Translation, regarded as the main energy consumption process, lies at the center of interest, as it has a significant impact on the longevity phenomenon. It has been shown that perturbations in the translational apparatus may lead to a lower rate of aging. Therefore, the main aim of this study was to investigate aging in relation to the protein biosynthesis circuit, taking into account the uL11 ribosomal protein as a vital ribosomal element. To this end, we used set of yeast mutants with deleted single uL11A or uL11B genes and a

SUBMITTER: Molon M 

PROVIDER: S-EPMC7409069 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature