The Complex Relationship Between Serum Uric Acid, Endothelial Function and Small Vessel Remodeling in Humans.

ABSTRACT: The relationship between serum uric acid (SUA) and microvascular remodeling in humans remains largely unexplored. We assessed whether SUA provides additional information on the severity of microvascular remodeling than that obtained from the European Heart Score (HS), the patterns of microvascular remodeling associated with changes in SUA levels and the mediation by endothelial function and nitric oxide (NO) availability on this relationship. A total of 162 patients included in the microvascular dataset of the Italian Society of Hypertension with available information on SUA, media-to-lumen (M/L) ratio, media cross-sectional area (MCSA), endothelial function, NO availability and HS were included in the analysis. The top tertile of M/L ratio and MCSA were used to define severe microvascular

SUBMITTER: Masi S 

PROVIDER: S-EPMC7409082 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature