Immunoadsorption and Plasma Exchange in Seropositive and Seronegative Immune-Mediated Neuropathies.

ABSTRACT: The inflammatory neuropathies are disabling conditions with diverse immunological mechanisms. In some, a pathogenic role for immunoglobulin G (IgG)-class autoantibodies is increasingly appreciated, and immunoadsorption (IA) may therefore be a useful therapeutic option. We reviewed the use of and response to IA or plasma exchange (PLEx) in a cohort of 41 patients with nodal/paranodal antibodies identified from a total of 573 individuals with suspected inflammatory neuropathies during the course of routine diagnostic testing (PNAb cohort). 20 patients had been treated with PLEx and 4 with IA. Following a global but subjective evaluation by their treating clinicians, none of these patients were judged to have had a good response to either of these treatment modalities. Sequential serology of

SUBMITTER: Davies AJ 

PROVIDER: S-EPMC7409112 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature